Mesothelin/GPC3/GUCY2C-CAR-T Cells Against Cancers
Recruiting
Phase 1
Interventional Study
Pancreas Cancer
CAR-T Cell Therapy
Mesothelin
Solid Tumor, Adult
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 30 (estimated)
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University · Other
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About This Trial
The second generation of mesothelin targeted CAR-T cells that secret a fusion protein of IL21 and scfv against PD1 have been constructed and their anti-cancer function has been verified by multiple in vitro and in vivo studies. Clinical studies will be performed to test anti-cancer function of the CAR-T cells for immunotherapy of human cancer patients with Mesothelin expressions. In this phase I s…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1\. Patients with advanced cancer that expresses Mesothelin protein; 2. Life expectancy \>12 weeks; 3. Adequate heart, lung, liver, kidney, and blood function; 4. Available autologous transduced T cells with greater than or equal to 20% expression of Mesothelin-CAR determined by…
Contacts