The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
Recruiting
N/A
Interventional Study
Air Pollution
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 40
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 120 (estimated)
- Sponsor
- Rutgers, The State University of New Jersey · Other
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About This Trial
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
Trial Locations
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Eligibility Criteria
Exclusion Criteria:
* Cardiovascular disease
* Respiratory disease
* Recent (within 4 weeks) respiratory or COVID-19 symptoms
* Diabetes
* Pregnancy
* HIV Infection
* History of smoking within the past 5 years.
* Orthopedic or rheumatologic conditions which would interfere with cycle use
* Inabilit…
Contacts