RO7656594 for Advanced or Metastatic Prostate Cancer

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Recruiting Phase 1 Interventional Study
Advanced Prostate Cancer Metastatic Prostate Cancer
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Male
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
210 (estimated)
Sponsor
Genentech, Inc. · Industry
Who this trial is looking for

This trial is looking for men with advanced or metastatic prostate cancer. Participants will receive a study treatment called RO7656594, and the trial will check how safe it is and how well it works.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have metastatic prostate cancer.
  • I have had treatment with second-generation androgen receptor therapies.
  • I have had prior treatment with a taxane regimen or refused it.
  • I have a known BRCA1 or BRCA2 mutation and had treatment with a PARP inhibitor.

You may not be able to join if

  • I have had any approved anti-cancer therapy in the last 14 days.
  • I have used any investigational agent in the last 28 days.
  • I have treated with any previous AR protein degrader.
  • I have untreated central nervous system metastases.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of RO7656594 in participants with advanced or metastatic prostate cancer. It will also identify recommended doses and regimens for RO7656594 for subsequent studies.

Trial Locations
Loading…

Loading trial locations…

Eligibility Criteria
Key Inclusion Criteria: 1. Eastern Cooperative Oncology Group (ECOG) performance status ≤1. 2. Metastatic prostate adenocarcinoma without small-cell carcinoma or neuroendocrine features. 3. Prior therapy with a second-generation androgen receptor (AR)-targeted therapy (e.g., abiraterone, enzalutami…
Contacts

GO44537 https://forpatients.roche.com/ No attachments to email below.

888-662-6728 (U.S. Only)

global-roche-genentech-trials@gene.com

CONTACT

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

CONTACT