Determining the Mechanisms of Loss of CAR T Cell Persistence
Recruiting
Observational Study
Acute Lymphoblastic Leukemia With Failed Remission
Acute Lymphoblastic Leukemia Not Having Achieved Remission
Acute Lymphoblastic Leukemia, Pediatric
Acute Lymphoblastic Leukemia, Adult
Acute Lymphoblastic Leukemia, in Relapse
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- Up to 25
- Sex
- Any
- Study type
- Observational
- Participants needed
- 50 (estimated)
- Sponsor
- University College, London · Other
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
1. Children and young adults (age 25 years or younger) with relapsed/refractory ALL who are planned to receive licensed CD19-targeted CAR-T cell treatment (Tisagenlecleucel)
2. Written informed consent
Exclusion Criteria:
1. Patients receiving an alternate CD19-directed CAR T-…
Contacts