Vericiguat for Kidney and Brain Injury in Heart Surgery
SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
Recruiting
Phase 4
Interventional Study
Endothelial Dysfunction
Vascular Diseases
Kidney Injury
Brain Disease
Vascular Inflammation
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 170 (estimated)
- Sponsor
- Vanderbilt University Medical Center · Other
Who this trial is looking for
This trial is looking for patients who are planning to have open-heart surgery. Participants will take either a medication called vericiguat or a placebo to see how it affects their blood vessels and markers of kidney and brain injury.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older
- I am scheduled for elective open-heart surgery
You may not be able to join if
- I cannot tolerate the medication vericiguat
- I am pregnant or breastfeeding
- I had kidney replacement therapy in the last 30 days
- My kidney function is very low
- My blood pressure is below 120 mmHg
- I have had a kidney transplant
- I have significant liver problems
- I currently have an active infection
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
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Answer a few quick questions to see if you may meet the eligibility requirements.
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About This Trial
The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and markers of kidney and brain injury in patients having heart surgery. The main questions it aims to answer are:
1. Does soluble guanylyl cyclase stimulation improve blood vessel function compared to placebo?
2. Does soluble guanylyl cyclase s…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age ≥18 years
2. Elective open-heart surgery, defined as surgery on the heart or aorta that requires sternotomy or thoracotomy
Exclusion Criteria:
1. Intolerance to vericiguat
2. Use of other soluble guanylyl cyclase stimulators or current use of phosphodiesterase-5 inhibit…
Contacts
No contact information available.