Trial of Variable Dialysate Bicarbonate
Recruiting
N/A
Interventional Study
Peri-dialytic Cardiac Rhythms
Intradialytic Hypotension
Electrolyte Changes
pH Changes
Adverse Symptoms
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 120
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 141 (estimated)
- Sponsor
- Brigham and Women's Hospital · Other
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About This Trial
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.
It is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions.
This study aims to assess the effects of lower (30 mEq/L) versus higher (35 mEq/L) dialysate bicarbonate in adult maintenance HD patients adm…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* prevalent end-stage renal disease, on maintenance HD \> 90 days
* age ≥ 18 years old
* thrice weekly HD
Exclusion Criteria:
* hemoglobin \< 8.0 g/dL
* pregnancy
* any physical, mental or medical condition which limited the ability to provide written informed consent
Contacts