No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
80 (estimated)
Sponsor
Medical University of South Carolina · Other
Who this trial is looking for
This trial is looking for people with Parkinson's Disease who are planning to have Deep Brain Stimulation. Participants will have a few visits for screenings, MRI scans, and cognitive assessments.
Are You a Good Fit for This Trial?
You may be able to join if
I am over 18 years old.
I will undergo Deep Brain Stimulation surgery for Parkinson's Disease.
You may not be able to join if
I have uncorrected visual or hearing impairments.
I am pregnant or expect to become pregnant during the study.
I have claustrophobia or cannot lie on my back for an MRI.
I have COPD and need oxygen.
I have non-MRI compatible metal implants.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hou…
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
Trial Locations
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Eligibility Criteria
PD Participants
Inclusion Criteria:
* Subjects above 18 years of age
* Subjects who will undergo DBS surgery as part of their clinical care for PD
Exclusion Criteria:
* Uncorrected visual or hearing impairments, as indicated by self-report
* Individuals who are pregnant or expect to become pregn…
PD Participants
Inclusion Criteria:
* Subjects above 18 years of age
* Subjects who will undergo DBS surgery as part of their clinical care for PD
Exclusion Criteria:
* Uncorrected visual or hearing impairments, as indicated by self-report
* Individuals who are pregnant or expect to become pregnant during the course of the study
* Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
* COPD with oxygen dependence
* Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
Non-PD Control Participants
Inclusion Criteria:
* Subjects above 18 years of age
* Age matched to participants in PD group
Exclusion Criteria:
* Diagnosis of Parkinsons Disease or other movement disorder
* Untreated neuropsychiatric disorders
* Uncorrected visual or hearing impairments, as indicated by self-report
* Individuals who are pregnant or expect to become pregnant during the course of the study
* Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
* COPD with oxygen dependence
* Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
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