The Clinical Course and Factors for the Progression of Uninvestigated Dyspepsia to Functional Dyspepsia
Recruiting
Observational Study
Dyspepsia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
220 (estimated)
Sponsor
Air Force Military Medical University, China · Other
Who this trial is looking for
This trial is looking for adults with a recent start of dyspepsia symptoms lasting more than 1 month. Participants will help researchers understand how dyspepsia can progress over time.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years old or older
I have first-onset dyspepsia symptoms
My symptoms have lasted more than 1 month but less than 3 months
You may not be able to join if
I have a known active peptic ulcer
I have a known injury to my liver or kidney
I have serious blood or hormonal disorders
I have a known cancer
I have heart or brain problems
I have other known conditions causing dyspeptic symptoms
I am pregnant or breastfeeding
I cannot give my consent
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Dyspepsia is one of the most common gastrointestinal diseases. This disease was defined as predominant epigastric pain lasting for at least 1 month, which can be accompanied with other symptoms, such as epigastric fullness, and early satiety. Despite dyspepsia symptoms lasting for ≥1 month represented clinical problem, a longer duration of 6 months or more after first-onset symptom was required fo…
Dyspepsia is one of the most common gastrointestinal diseases. This disease was defined as predominant epigastric pain lasting for at least 1 month, which can be accompanied with other symptoms, such as epigastric fullness, and early satiety. Despite dyspepsia symptoms lasting for ≥1 month represented clinical problem, a longer duration of 6 months or more after first-onset symptom was required for the diagnosis of functional dyspepsia based on ROME IV criteria. It was unclear about the natural procession of first-onset dyspepsia to functional dyspepsia assessed by Rome IV or Asia criteria and possible factors associated with this progression.
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Eligibility Criteria
Inclusion Criteria:
* Patients aged ≥ 18 years old who had first-onset dyspepsia with one or more symptoms of epigastric pain, epigastric burning, postprandial fullness, early satiation and that has lasted for more than 1 month to 3 months.
Exclusion Criteria:
1. Patients with local or systemic d…
Inclusion Criteria:
* Patients aged ≥ 18 years old who had first-onset dyspepsia with one or more symptoms of epigastric pain, epigastric burning, postprandial fullness, early satiation and that has lasted for more than 1 month to 3 months.
Exclusion Criteria:
1. Patients with local or systemic diseases which may cause dyspeptic symptoms:
Known active peptic ulcer, cholecystitis, gallstone, gastrointestinal obstruction, gastroparesis, and etc.
2. Known acute or chronic injury of liver or kidney
3. Obvious hematological abnormality, or endocrine and metabolic diseases
4. Known malignancy; Obvious cardiovascular or cerebrovascular diseases (such as coronary heart disease, arrhythmia, cerebral infarction and etc.
5. Other conditions which may be associated with dyspeptic symptoms (such as NSAIDs associated dyspepsia)
6. organ failure defined by Marshall standard or severe psychiatric illnesses
7. pregnancy or lactation
8. unable to provide consent
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