High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium

Inclusion Criteria: * Subject must be at least 40 years of age. * Asymptomatic patients with presence of coronary calcification (Agatston Score ≥ 100) * low-density lipoproteins cholesterol (LDL-C) \<190 mg/dL Exclusion Criteria: * Objective evidence of at least moderate inducible ischemia requiring revascularization treatment * History of cerebrovascular disease * History of coronary or peripheral arterial revascularization * Active liver disease or persistent unexplained serum transaminase elevations more than 2 times the upper limit of normal range * History of any adverse drug reaction requiring discontinuation of statin (e, g. rhabdomyolysis) * Allergy or sensitivity to any statin or ezetimibe * Concurrent treatment with cyclosporine or a condition likely to result in organ transplantation and the need for cyclosporine * Pregnancy or breast feeding * Non-cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment) * Unwillingness or inability to comply with the procedures described in this protocol.