No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
30 – 85
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
90 (estimated)
Sponsor
University of Nevada, Las Vegas · Other
Who this trial is looking for
This trial is looking for adults aged 30-85 with Parkinson's disease or healthy adults to explore how exercise might help reduce inflammation in the body. Participants will engage in 30 minutes of moderate exercise with a few short breaks.
Are You a Good Fit for This Trial?
Rules you outDementia
You may be able to join if
I am between 30 and 85 years old.
I have been diagnosed with Parkinson's disease by a doctor.
I can do 30 minutes of moderate exercise with some short breaks.
I have no major medical diagnoses if I am a control.
You may not be able to join if
I have a medical condition that prevents me from exercising.
I am not ready to participate in exercise.
I have dementia.
I have severe asthma that is triggered by exercise.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a prog…
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.
Trial Locations
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Eligibility Criteria
Inclusion criteria for PwP:
* 30-85 years old
* Neurologist-diagnosed PD
* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.
Inclusion criteria for controls:
* 30-85 years old
* No major medical diagnoses
* Able to participate in 30 m…
Inclusion criteria for PwP:
* 30-85 years old
* Neurologist-diagnosed PD
* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.
Inclusion criteria for controls:
* 30-85 years old
* No major medical diagnoses
* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.
Exclusion Criteria for both PD group and controls:
* Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma).
* Those not deemed ready for exercise participation. Participants will be screened for exercise participation using the Physical Activities Readiness Questionnaire + which is used as a screening tool for all ages to identify risk factors that would clear someone for participation in moderate physical exercise.
* Those with dementia will be excluded because there are self-report questionnaires in this study. This will be identified using the Montreal Cognitive Assessment and a score at or below a 21. Participants with mild cognitive impairment and no impairment will be included.
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