No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
45 (estimated)
Sponsor
University of North Carolina, Chapel Hill · Other
Who this trial is looking for
This trial is looking for people with Parkinson disease to join a walking training program. Participants will train to walk better using a metronome over 12 sessions, which will last about an hour each, and will involve walking tests and MRI scans.
Are You a Good Fit for This Trial?
Must be takingLevodopa
You may be able to join if
I have been diagnosed with idiopathic Parkinson's disease.
I can walk for 10 minutes without help from a therapist.
My walking speed is between 0.4 m/s and 1.2 m/s.
I can hear normally or with a hearing aid.
I have issues with how I walk, like shuffling or freezing.
My score on the MDS-UPDRS-III for movement is between 1 and 2.
I am taking stable doses of orally-administered levodopa.
I am between 50 and 80 years old.
You may not be able to join if
I have metal implants that prevent me from having an MRI.
I have cognitive difficulties.
I am currently receiving Physical Therapy.
I have had deep brain stimulation surgery.
I cannot walk without help from a therapist.
I have uncontrolled heart or lung disease.
I have other neurological disorders or injuries affecting my walking.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on …
The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on the treadmill is intended to help participants take larger steps. The use of a faster frequency metronome while walking overground is intended to help participants take faster steps.This will take place over 12 training sessions. Each session will be about an hour. It will include some walking tests and pictures of the brain (using MRI) before and after training.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* idiopathic Parkinson's disease (Hoehn and Yahr Stage 2-3)
* self-report the ability to walk uninterrupted for 10 minutes both overground and on a treadmill without therapist assistance
* comfortable gait speed \> 0.4 m/s and \< 1.2 m/s
* normal (or corrected to normal \[i.e., …
Inclusion Criteria:
* idiopathic Parkinson's disease (Hoehn and Yahr Stage 2-3)
* self-report the ability to walk uninterrupted for 10 minutes both overground and on a treadmill without therapist assistance
* comfortable gait speed \> 0.4 m/s and \< 1.2 m/s
* normal (or corrected to normal \[i.e., hearing aid\]) hearing
* deficits in gait continuity (e.g., shuffling, shortened strides, freezing, festination, bradykinesia, etc) based on observational gait analysis
* Movement Disorders Society - Unified Parkinson Disease Rating Scale (MDS-UPDRS-III) item 10 ≥1 and \<3
* be on stable doses of orally-administered levodopa
* age 50-80 years old
Exclusion Criteria:
* contraindications to MRI (e.g., metal implants, claustrophobia, etc)
* cognitive deficits (Montreal Cognitive Assessment \[MoCA\] \< 26)
* concurrent Physical Therapy
* have undergone deep brain stimulation surgery
* cannot walk without therapist assistance
* uncontrolled cardiorespiratory/metabolic disease, or other neurological disorders or orthopedic injury that may affect gait.
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