Supplemental Oxygen in Pulmonary Embolism (SO-PE)
Recruiting
Early Phase 1
Interventional Study
Pulmonary Embolism
Venous Thromboembolism
Metabolomics
Oxygen Inhalation Therapy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 80 (estimated)
- Sponsor
- Massachusetts General Hospital · Other
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About This Trial
A study of how supplemental oxygen helps patients with acute pulmonary embolism (PE). Hypothesis: Oxygen affects right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE) primarily by relieving hypoxic pulmonary vasoconstriction and reducing pulmonary pressure (PA) pressure, and that this process is metabolically driven.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults ≥18 years old
* Confirmed Pulmonary Embolism (PE) on imaging \<24 hours prior to enrollment
* New symptom onset and / or worsening symptoms \<72 hours
* Confirmation of right ventricular dysfunction (RVD) by clinician
* Oxygen saturation ≥90% while breathing room air
E…
Contacts