Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
Recruiting
N/A
Interventional Study
Bordetella Pertussis, Whooping Cough
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- Up to 15
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 210 (estimated)
- Sponsor
- Institut Pasteur · Industry
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About This Trial
The resurgence of pertussis is associated with an evolutionary mechanism under the pressure of current acellular vaccines, with a possible impact on vaccine effectiveness and disease expression. Little is known about the mechanisms involved in the clinical variability of pertussis, including its most severe malignant form observed in infants (mortality between 50-80%). The main challenges are: (i)…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* be between the ages of 0 and 15 years inclusive
* be suspected of having pertussis by the physician in charge, with the prescription of a diagnostic PCR (pertussis PCR, which may be a syndromic PCR, a PCR targeting IS481 and/or IS1001)
* be free of any pathology/treatment that…
Contacts