Noninvasive Breathing Support for Severely Obese Patients
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Recruiting
N/A
Interventional Study
Obesity, Morbid
Extubation Failure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 250 (estimated)
- Sponsor
- Rush University Medical Center · Other
Who this trial is looking for
This trial is looking for adults with severe obesity who are being taken off a breathing tube. Participants will receive noninvasive breathing support to see if it helps them breathe without needing the tube again.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older
- I have been on a breathing machine for at least 24 hours
- I have a BMI of 40 or higher
- I am scheduled to have the breathing tube removed
- My blood pH levels are within acceptable ranges
You may not be able to join if
- I am pregnant
- I have a chronic tracheostomy
- I accidentally had my breathing tube removed
- I have a serious respiratory condition like COPD
- I have a history of chronic respiratory failure requiring home support
- My doctor believes I should not use noninvasive support
- I or my family do not want reintubation if needed
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive bre…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Adult, age ≥ 18 years old
2. Receiving invasive mechanical ventilation for ≥24 hours
3. BMI ≥40 kg/m2
4. Undergoing planned extubation per treating team
5. Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)
Exclusion Criteria:
1. Pregn…
Contacts