Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors

Inclusion Criteria: * 18-70 years of age * Previous diagnosis of stage II-III CRC cancer * No known current, recurrent, or metastatic disease * No comorbid or physical limitations that would limit participation at the discretion of the treating provider * At least 60 days to 3 years from last cancer-directed treatment (including surgery, chemotherapy, and radiation. Elective surgery, including ileostomy reversal, is not counted in this timing but patients must be able to eat a normal diet, without post-operative dietary limitations) * Body mass index (BMI) 18.5-35 kg/m\^2 * Able to understand and willing to sign written informed consent in English * Access to phone for study contacts * Access to a smart phone or tablet to connect to the Polar H10 Heart rate sensor during remote exercise sessions and attend virtual exercise sessions * Be willing and able to attend up to 24 sessions in-person at the Fred Hutch Exercise Research Center Shared Resource or virtually via phone, Zoom, or Microsoft Teams, based on participant preference * Access to internet (internet access may be provided on a case-by-case basis to participants where access to internet would otherwise be the only barrier to participation) * Willingness to participate in all study activities * Completion of all run-in activities * Participants must have an Eastern Cooperative Oncology Group (ECOG) Scale of Performance Status score of 0 or 1 for performance status * Women must not be pregnant, breastfeeding, or planning to become pregnant Exclusion Criteria: * Use of oral or intravenous antibiotics, antifungals, or antiparasitics during the past 6 months * Presence of an ileostomy or colostomy because of known changes to the gut microbiome with ileostomies and colostomies * Current status of underweight (BMI \< 18.5 kg/m\^2) or class II/III obesity (BMI ≥ 35.0 kg/m\^2) * Presence of inflammatory bowel diseases such as Crohn's disease or ulcerative colitis as these are known to baseline have differences in gut microbiome composition * Women who are pregnant, breastfeeding, or planning to become pregnant * Physician notification to not approach patient for the study