Small Extracellular Vesicles and Insulin Action
Recruiting
N/A
Interventional Study
Obesity
Insulin Resistance
Metabolically Healthy Obesity
Obesity, Metabolically Benign
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 25 – 55
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 72 (estimated)
- Sponsor
- Washington University School of Medicine · Other
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About This Trial
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Metabolically healthy lean subjects must have a BMI ≥18.5 and ≤24.9 kg/m²; Subjects with obesity must have a BMI ≥30.0 and ≤50.0 kg/m²
* Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride (IHTG) content ≤5%; fasting pla…
Contacts