Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis
Recruiting
N/A
Interventional Study
Chronic Histiocytic Intervillositis
Intrauterine Growth Retardation
Fetal Death in Utero
Miscarriage
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 200 (estimated)
- Sponsor
- Assistance Publique - Hôpitaux de Paris · Other
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About This Trial
Chronic histiocytic intervillositis (CHI) is a rare condition with an incidence of 5 in 10,000 pregnancies. This rare condition is associated with placental inflammatory lesions leading to severe and recurrent obstetrical complications: intrauterine growth retardation (IUGR), fetal death in utero and miscarriage. The pathophysiological mechanisms of CHI are poorly understood, while the empirical t…
Trial Locations
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Eligibility Criteria
Family Inclusion Criteria:
* Mother and father ≥ 18 years old
* For mothers in the CHI group :
* History of a normal pregnancy (full term, alive child) or IUGR/MFIU or miscarriage(s) or abortion followed by at least 1 obstetrical complication such as IUGR, MFIU, miscarriage
* Diagnosis of chro…
Contacts