Study on the Relationship Between Plasma MRD and cfDNA HPV and the Efficacy and Prognosis of Locally Advanced Cervical Cancer After Concurrent Chemoradiotherapy

Inclusion criteria * Age: ≥ 18 years old, ≤ 75 years old. * Pathological histologic confirmation of cervical cancer. * Imaging or PET/CT examination can be performed to understand the tumor and complete all follow-up. * Measurable lesions before treatment. * Good physical condition: ECOG score 0-1 (or KPS score 70-100). * Estimated survival≥ 6 months. * The baseline blood routine and biochemical indexes before radiotherapy and chemotherapy met the following standards: hemoglobin ≥ 80g/L, absolute neutrophil count (ANC) ≥ 1.5×109/L, platelet ≥ 100×109/L, ALT, AST ≤ 2.5 times the normal upper limit; Serum albumin ≥ 30 g/L. * There are three preoperative items: if the patient has syphilis, plum repellent therapy is required before treatment. * The patient has no history of allergy to rubber products. * Cardiopulmonary function is basically normal Exclusion Criteria: * Those who are allergic to rubber products. * Those with severe acute infection and uncontrolled or purulent and chronic infection wounds that do not heal, chronic hepatitis B active stage, active tuberculosis, syphilis outbreak and AIDS. * Patients with pre-existing severe heart disease, including: congestive heart failure, uncontrollable high-risk arrhythmia, unstable angina, myocardial infarction, severe valvular heart disease, and intractable hypertension. * Those with neurological or psychiatric diseases or mental disorders that are not easy to control, poor compliance, unable to cooperate with and describe treatment responses, uncontrolled primary brain tumors or central nervous system metastases, and those with obvious cranial hypertension signs or neuropsychiatric symptoms. * with malignant serous effusion. * History of severe enteritis and cystitis, bleeding, intestinal perforation, rectovaginal fistula, rectoval bladder fistula, etc. * Those who have participated in other clinical trials. * Other situations in which the investigator believes that the subject is not suitable to participate in this experiment