Mitochondrial Substrate Utilization in the Diabetic Human Heart
Recruiting
Observational Study
Heart Failure
Type2diabetes
Insulin Resistance
Mitochondrial Diseases
Diabetic Cardiomyopathies
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 20 – 85
- Sex
- Any
- Study type
- Observational
- Participants needed
- 500 (estimated)
- Sponsor
- Heinrich-Heine University, Duesseldorf · Other
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About This Trial
Diabetes can lead to heart failure independently, but the underlying causes remain incompletely understood. The main aim of this study is to identify differential regulation of mitochondrial substrate utilization and complex activity in heart failure and type 2 diabetes mellitus (T2DM). For this, we will conduct a prospective, observational study to examine myocardial mitochondrial oxidative funct…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 20 and ≤ 85 years
* Male and female patients with manifest heart failure (NYHA II-IV) and clinical indication for myocardial biopsy or after transplantation and clinical indication for myocardial biopsy with or without type II diabetes mellitus or terminal (NYHA IV) hear…
Contacts