Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
Recruiting
Phase 1
Interventional Study
Nicotine Dependence
Nicotine Vaping
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 21 – 65
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 18 (estimated)
- Sponsor
- University of California, San Francisco · Other
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About This Trial
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Healthy on the basis of medical history and limited physical examination.
* Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)
Exclusion Criteria:
* • Medications
* Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rif…
Contacts