New Method for Improving Sperm Quality in Infertility
Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters
Recruiting
N/AInterventional Study
Infertility
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Sex
Male
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
Professor Ernest Hung-Yu Ng · Other
Who this trial is looking for
This trial is looking for men who have difficulties with fertility to compare two methods for processing semen. Participants will provide semen samples that will be tested to see which method results in better sperm quality.
Are You a Good Fit for This Trial?
You may be able to join if
I have at least 5 million moving sperm per ml in my semen
I can provide an ejaculated semen sample
My semen volume is at least 1.5 ml
You may not be able to join if
I have less than 5 million moving sperm per ml in my semen
I cannot provide an ejaculated semen sample
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high. Semen quality can affect IVF outcomes, and the current method used to process semen can damage the sperm and DNA. Scientists are now testing a new method called microfluidic chip technology, which reduces DNA damage and increases …
Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high. Semen quality can affect IVF outcomes, and the current method used to process semen can damage the sperm and DNA. Scientists are now testing a new method called microfluidic chip technology, which reduces DNA damage and increases sperm movement. This study will compare the effectiveness of the chip method and the current method on semen quality in men attending a fertility clinic. The study will randomly assign semen collected to one of the two methods and assess the semen quality using different tests, as well as the difference in using two different microfluidic chip platform . The primary outcome will be DNA fragmentation, and other outcomes include sperm count and motility. Semen samples would be collected from study subjects for analysis and that both the samples and results would not be used in patients' treatment.
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Eligibility Criteria
Inclusion Criteria:
* Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml.
Exclusion Criteria:
* Sperm concentration of the raw semen of less than 5 million motile sperm per ml
* Men unable to provide an ejaculated semen samp…
Inclusion Criteria:
* Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml.
Exclusion Criteria:
* Sperm concentration of the raw semen of less than 5 million motile sperm per ml
* Men unable to provide an ejaculated semen sample
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