Emotional Reactivity Study for Nonsuicidal Self-Injury
Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents
Recruiting
Observational Study
Nonsuicidal Self InjuryPrediction Errors
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
15 – 18
Sex
Any
Study type
Observational
Participants needed
80 (estimated)
Sponsor
University of Electronic Science and Technology of China · Other
Who this trial is looking for
This trial is looking for adolescents aged 15-18 who have engaged in nonsuicidal self-injury. Participants will help researchers understand how emotional responses affect decision-making in social situations.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 15 and 18 years old.
I am right-handed.
I have normal or corrected normal vision.
I have engaged in nonsuicidal self-injury at least 5 times in the past year.
You may not be able to join if
I have been diagnosed with borderline personality disorder.
I have been diagnosed with major depressive disorder.
I have a high risk of suicide.
I have recently used medications that can affect brain activity.
I have received Dialectical Behavior Therapy in the past 6 months.
I have any condition that makes MRI unsafe for me.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the …
Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.
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Eligibility Criteria
Inclusion Criteria:
* 15-18 years
* right-handed
* normal or corrected normal visual acuity
* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)
Exclusion Criteria:
* diagnosis of borderline personality disorder, major depressive disorder, other
* psychi…
Inclusion Criteria:
* 15-18 years
* right-handed
* normal or corrected normal visual acuity
* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)
Exclusion Criteria:
* diagnosis of borderline personality disorder, major depressive disorder, other
* psychiatric disorders, etc.
* high suicidal risk
* recent use of medications that can affect neural activity
* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)
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