Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Recruiting
N/A
Interventional Study
Systemic Sclerosis
Constipation
Gastrointestinal Motility Disorder
Autonomic Dysfunction
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- The University of Texas Health Science Center, Houston · Other
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About This Trial
The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inf…
Trial Locations
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Eligibility Criteria
Inclusion Criteria
* Patients with SSc-constipation from Aim 1 of the study
* Patients with SCT (\>20% radiopaque marks left in the colon 5 days (120 hours) after swallowing the Sitzmark capsule or patients with RH (defined in Aim 1)
* Patients not yet on therapy for constipation or patients who co…
Contacts