Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study
Recruiting
Observational Study
High-grade Glioma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 70
Sex
Any
Study type
Observational
Participants needed
500 (estimated)
Sponsor
RenJi Hospital · Other
Who this trial is looking for
This trial is looking for adults with high-grade gliomas to see how MRI images can help understand their condition and predict outcomes. Participants will undergo an MRI scan and provide medical information after their diagnosis.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 70 years old.
I have been diagnosed with high-grade glioma.
I have had a standard MR scan before my surgery.
I have not received any radiotherapy or chemotherapy before surgery.
I do not have other serious medical conditions.
I have the results of relevant genetic tests.
I can provide complete medical and follow-up information.
You may not be able to join if
My MRI images have artifacts or bleeding.
I have claustrophobia that prevents me from having an MRI.
I have had allergic reactions to MRI contrast agents.
I cannot cooperate for a 40-minute MRI scan.
I have another tumor.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
1. To retrospectively explore the feasibility of multi-dimensional heterogeneity imaging features of MRI in predicting the status of key gene mutations in high-grade gliomas;
2. To prospectively explore the correlation between multi-dimensional heterogeneous MRI image features and prognosis of high-grade glioma patients.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
Retrospective Study:
1. Participants aged 18 to 70 years, of any gender.
2. Confirmed postoperative pathology of adult diffuse glioma (WHO Grade III-IV).
3. Standard MR contrast-enhanced imaging performed within 10 days before surgery.
4. No history of prior radiotherapy or che…
Inclusion Criteria:
Retrospective Study:
1. Participants aged 18 to 70 years, of any gender.
2. Confirmed postoperative pathology of adult diffuse glioma (WHO Grade III-IV).
3. Standard MR contrast-enhanced imaging performed within 10 days before surgery.
4. No history of prior radiotherapy or chemotherapy before surgery.
5. Absence of concurrent significant comorbidities or other tumors.
6. Presence of molecular testing results (including IDH, MGMT, 1p19q, TERT, CDKN2A/B, BRAF).
7. Availability of comprehensive clinical and follow-up data.
Prospective Study:
1. Participants aged 18 to 70 years, of any gender.
2. Clinically suspected to have high-grade gliomas preoperatively, with final pathology confirming high-grade gliomas.
3. Stable vital signs and capable of cooperating for a 40-minute MR scan.
4. Absence of significant underlying medical conditions or history of other tumors.
5. Documentation of informed consent through a signed consent form.
Exclusion Criteria:
Retrospective Study:
1. MRI images with artifacts or presence of intratumoral hemorrhage.
2. Incomplete clinical data available.
Prospective Study:
1. Individuals with claustrophobia or other reasons unable to undergo MRI scans.
2. History of allergic reactions to MRI contrast agents.
3. Inappropriate for prolonged MRI scans due to other reasons.
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