An Imaging Study of Polyvascular Disease

Inclusion Criteria: Task 1: 1. Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography) 2. Age ≥18 years old 3. Proposed OCT-IVUS integrated imaging system 4. able to provide written informed consent prior to the start of any procedures related to the study. Task 2: 1. patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist) 2. Age ≥ 18 years 3. able to provide written informed consent prior to the start of any procedures related to the study. Exclusion Criteria: Task 1: 1. severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system 2. uncontrolled congestive heart failure or acute left heart failure;plan 3. claustrophobia; 4. left main stem occlusion; 5. proposed coronary artery bypass grafting (CABG); 6. uncontrolled severe ventricular arrhythmia; 7. active bleeding or severe bleeding tendency; 8. acute stroke; 9. patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ; 10. severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned; 11. contraindications to the application of contrast media; 12. patients who are severely uncooperative due to psychiatric or serious systemic illness; 13. Patients who, in the opinion of the investigator, are unsuitable for participation in the study. Task 2: 1. patients who are unable to comply with the follow-up schedule; 2. uncontrolled congestive heart failure or acute left heart failure; 3. patients with a life expectancy of less than 6 months; 4. left main stem occlusion; 5. proposed coronary artery bypass grafting (CABG); 6. uncontrolled severe ventricular arrhythmia; 7. active bleeding or severe bleeding tendency; 8. patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ; 9. severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned; 10. contraindications to the application of contrast media; 11. patients who are severely uncooperative due to psychiatric or serious systemic illness; 12. patients who, in the opinion of the investigator, are not suitable for participation in the study.