Cerebrovascular Health and Resilience in Midlife

Inclusion Criteria: * Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania) * Able to read and speak English Exclusion Criteria: * Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg) * Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications * Current use of glucocorticoids (e.g., oral prednisone) or ephedrine * Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers) * Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury) * Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia) * Current pregnancy or childbirth within the past 6 months * Suspected mild cognitive impairment or dementia * Self reported sleep apnea * Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias * Self-reported lack of comfort to undergo MRI testing * Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing * Self-reported lack of comfort to undergo the laboratory math task