Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years
Recruiting
Observational Study
Influenza
Community-acquired Pneumonia
Cardiovascular Events
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 65 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 1,500,000 (estimated)
- Sponsor
- Kaiser Permanente · Other
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About This Trial
This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023/24, 2024/25, and 2026/27 influenza seasons. The study is an obser…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥65 years at the time of influenza vaccination
* KPNC member at the time of vaccination
* Receive either aIIV4 or HD-IIV4 at a KPNC facility during the 2023/24 and/or 2024/25 influenza seasons
Exclusion Criteria:
* Age \<65 years at the time of influenza vaccination
* Re…
Contacts