Exercise Training on Brain Insulin Responsiveness

Inclusion Criteria: * BMI between ≥ 19.5 to 39 kg/m2- * Less than 150 min/week for moderate-intensity physical activity * Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults) * Written consent to participate in the study * Written consent to be informed about incidental findings Exclusion Criteria * Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke * Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, …) * Insufficient knowledge of the German language * Persons who cannot legally give consent * Pregnancy or lactation * History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures and migraines) * Taking psychotropic drugs * Taking medications that influence glucose metabolism * Regular use of analgesic drugs * Taking anticoagulant agents * Previous bariatric surgery * Acute infection within the last 4 weeks * Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men * Other diseases that in the opinion of the investigator may jeopardize the success of the study or indicate a risk to the volunteer * Current participation in a lifestyle intervention study or a pharmaceutical study * Metal implants which cannot be removed as pacemakers, artificial heart valve, electrical devices as insulin pumps, large tattoos, retainer over more than 4 teeth, contraceptive coil, implanted magnetic metal parts as screws or plates after a surgery * Persons with claustrophobia * Temperature-sensitive person * Persons with tinnitus or increased sensitivity to loud sounds