Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Recruiting
N/A
Interventional Study
Mild Cognitive Impairment
Alzheimer Disease
Hyperglycemia
Pre-sarcopenia
At a Glance
- Age
- 50 – 80
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 100 (estimated)
- Sponsor
- Chung Shan Medical University · Other
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About This Trial
The aim of the study is to investigate the effect of coenzyme Q10 supplementation (150 mg/b.i.d, 300 mg/d, 12 weeks) on coenzyme Q10, glucose parameters, BDNF, myokines, and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients who combined with hyperglycemia but without sarcopenia, or with hyperglycemia and pre-sarcopenia.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Clinical diagnosis of mild cognitive impairment (MCI).
* Clinical diagnosis of Alzheimer's Disease.
* MCI and AD patients with hyperglycemia ( Fasting glucose \>=100 mg/dL).
* MCI and AD patients with pre-sarcopenia (low calf circumference, low hand grip, or low muscle enduran…
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