Relation Between Venetoclax Plasma Concentration and Remission in Adults with Acute Myeloid Leukemia (PREDICLAX)

Inclusion Criteria: 1. Subject must have a confirmed diagnosis of previously untreated AML (ELN 2022 criteria) within 28 days of the onset of symptoms. Only previous cytoreductive treatments (e.g. hydroxyurea) are authorized. 2. Subject must be ineligible for standard cytarabine and anthracycline induction therapy according to the following criteria: * Subject aged ≥ 75 years. * OR subject aged between 60 and 74 with at least one of the following comorbidities: * ECOG performance status: of 2 or 3. * cardiac history: heart failure requiring treatment, left ventricular ejection fraction ≤ 50%, chronic stable angina. * carbon monoxide diffusion capacity ≤ 65% or forced expiratory volume in one second ≤ 65%. * creatinine clearance between 30 and 45 mL/min/m². * liver damage (not related to AML) with total bilirubin between 1.5 and 3 × upper normal limit. * any other comorbidity deemed by the physician to be incompatible with standard induction chemotherapy. 3. Patients are eligible for the recommended standard treatment, i.e. a combination of venetoclax and a hypomethylating agent. 4. Subjects must voluntarily sign and date an informed consent form authorized by the relevant authorities. 5. The participation of the subject in another interventional study not interfering with the pathophysiological, pharmacological and clinical rationale of this protocol is possible. Exclusion Criteria: 1. blood leukocytes \>25 G/L. 2. Subject has already received anticancer treatment (drugs, surgery, radiotherapy) for AML, hematological malignancy or malignant cancer (within the last 2 years). 3. Subjects with AML with central nervous system involvement or promyelocytic type (AML-M3). 4. Subject to an uncontrolled intercurrent disease such as: * infection (viral, bacterial or fungal) requiring treatment; * symptomatic congestive heart failure; * unstable angina pectoris * cardiac arrhythmia * psychiatric illness or drug addiction that would limit compliance with study requirements (risk of treatment non-adherence or low venous capital). 5. Documented hypersensitivity to the drugs used to treat the subject. 6. Subject has been exposed to potent CYP450 inducers or inhibitors (including grapefruit, Seville oranges) within 7 days prior to treatment initiation.