Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Recruiting
Observational Study
Delirium, Postoperative
Cognitive Decline
Dementia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 70 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 150 (estimated)
- Sponsor
- Massachusetts General Hospital · Other
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About This Trial
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are:
1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study.
2. To determine if plasma Alzheimer's disease (A…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \>= 70 years old
* Scheduled to undergo major orthopedic surgery
* Expected postoperative recovery of more than 24 hours as an inpatient
Exclusion Criteria:
* Cognitive impairment leading to inability to consent
* Patients with limited mobility or inability to wear an ac…
Contacts