No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 90
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
65 (estimated)
Sponsor
Emory University · Other
Who this trial is looking for
This trial is looking for people with stroke or neglect issues. Participants will undergo prism adaptation training to see how it affects their movement and walking abilities.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 30 years old and healthy.
I am between 45 and 90 years old and healthy.
I am 40 to 90 years old and had a right hemisphere stroke more than 3 months ago.
I can walk more than 10 meters with or without help.
I can understand and follow three-part instructions.
I can give my consent to participate.
You may not be able to join if
I have any physical disability or neurological disorder.
I am pregnant.
I have uncontrolled high blood pressure.
I have a pacemaker or another implanted electronic device.
I have skin issues at the site where electrodes would be placed.
I have dizziness that is unexplained and occurred in the past 6 months.
I have had a stroke in the brain stem.
I have severe uncontrolled health problems.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
Young Adults Able Bodied (YAB) Individuals
* 18-30 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
Older Adults Able-Bodied Individuals (OAB)
* 45-90 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
…
Inclusion Criteria:
Young Adults Able Bodied (YAB) Individuals
* 18-30 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
Older Adults Able-Bodied Individuals (OAB)
* 45-90 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
Individuals with right hemisphere stroke (40-90 years)
* \>3 months following stroke.
* Presence of Aiming SN
* Ability to walk \>10m with or without assistive devices.
* Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale
* Ability to follow 3-stage commands and provide informed consent.
Exclusion Criteria:
Young Adults Able-Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB)
* History or evidence of orthopedic or physical disability
* History or evidence of neurological pathology
* Pregnancy (female)
* Uncontrolled hypertension
* Cardiac pacemaker or other implanted electronic system
* Presence of skin conditions preventing the electrical stimulation setup
* Impaired sensation in the left upper limb.
* Bruises or cuts at the stimulation electrode placement site
* Concurrent enrollment in rehabilitation or another investigational study.
* History or evidence of orthopedic or physical disability interfering with study procedures
* History or evidence of neurological pathology or disorder
* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures
* Contraindications to TMS, such as metal implants, medications that can increase cortical excitability, and unexplained dizziness in the past 6 months
Individuals with right hemisphere stroke (40-90 years)
* History or brainstem strokes
* Cerebellar disorders
* Impaired sensation in the left upper limb.
* History of other neurological disorders
* Uncontrolled hypertension
* Cardiac pacemaker or other implanted electronic system
* Pregnancy (female)
* Presence of skin condition
* Bruises at the electrode placement site
* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures
* Contraindications to TMS, such as metal implants in the brain, medications that will increase cortical excitability, etc.
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