Somatic Mosaicism in Twins Discordant for Childhood Cancer
Recruiting
Observational Study
Pediatric Central Nervous System TumorCentral Nervous System TumorDiscordant TwinSomatic Mutation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
Up to 18
Sex
Any
Study type
Observational
Participants needed
50 (estimated)
Sponsor
Children's Oncology Group · Research network
Who this trial is looking for
This trial is looking for twins where one has a brain tumor and is under 19 years old. Participation includes providing consent and possibly donating a blood sample if the twin with the tumor has passed away.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with a brain tumor.
I am under 19 years old.
I have a same-sex twin.
I can provide informed consent.
My twin with the tumor is deceased but has a blood sample banked.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
* Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
* Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
*…
Inclusion Criteria:
* Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
* Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
* Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
* A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
* All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
* All institutional, FDA, and NCI requirements for human studies must be met.
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