No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 89
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
55 (estimated)
Sponsor
VA Office of Research and Development · Federal
Who this trial is looking for
This trial is looking for stroke survivors who have difficulty walking. Participants will take part in a high-intensity interval training program to see if it can help improve their walking speed.
Are You a Good Fit for This Trial?
You may be able to join if
I have had a stroke more than 6 months ago
I have trouble walking quickly, with a speed of less than 0.6 m/s
I am a military Veteran
You may not be able to join if
I have a pacemaker or cannot undergo an MRI scan
I have another neurodegenerative condition that affects my legs
I have visual or hearing problems that could interfere with the study
I have a medical condition that prevents me from exercising
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed…
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident
* lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk
* Veteran status
Exclusion Criteria:
* MRI contraindica…
Inclusion Criteria:
* chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident
* lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk
* Veteran status
Exclusion Criteria:
* MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia
* any neurodegenerative condition other than stroke that may lead to lower extremity impairment
* a visual or auditory impairment that may hinder study procedures
* any medical condition that would preclude participation in a physical exercise intervention program
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