Thiotepa, Cyclophosphamide, and Cytarabine for Blood Cancer

Thiotepa, Cyclophosphamide, Clarithromycin and Cytarabine

Recruiting Phase 1 Interventional Study
Burkitt Lymphoma Lymphoblastic Lymphoma, Adult Acute Lymphoblastic Leukemia, Adult
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
28 (estimated)
Sponsor
Fifth Affiliated Hospital, Sun Yat-Sen University · Other
Who this trial is looking for

This trial is looking for adults with certain types of blood cancer, such as Burkitt lymphoma and acute lymphoblastic leukemia. Participants will receive a specific treatment before undergoing a stem cell transplant, followed by one year of maintenance treatment to check for effectiveness and safety.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 18 and 65 years old.
  • I have been diagnosed with Burkitt lymphoma or acute lymphoblastic leukemia.
  • I received specific chemotherapy treatment before.
  • I can cooperate with the requirements of the study.
  • I have not had any cancer treatments in the last 3 years, except for certain skin cancers.
  • I have a performance status score of 0-2.
  • I have achieved remission or am at a specific treatment stage.

You may not be able to join if

  • I have a history of cancer and received treatment in the past 3 years.
  • I am pregnant or cannot take contraceptive measures.
  • I have tested positive for HIV or active hepatitis.
  • I have active heart disease or serious heart conditions.
  • I am planning major surgery in the next 4 weeks.
  • I have taken live vaccines within 4 weeks before the trial.
  • I have mental illness that interferes with my involvement.
  • I have participated in other clinical trials in the past month.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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Check Your Eligibility
About This Trial
This study is an observational study on the efficacy and safety of auto-HSCT in adult patients with Burkitt lymphoma, lymphoblastic lymphoma, and acute lymphoblastic leukemia who received TCCA conditioning regimen. The study plans to include 28 patients who received the TCCA regimen for pre-transplantation pretreatment before auto-HSCT. Maintenance treatment will be carried out after transplantati…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * 1\. Voluntarily sign the informed consent form, which must be signed by the patient himself. 2\. ALL patients confirmed by bone marrow cell morphology, immunology, and genetics; 3. PH+ALL patients who achieve s3CMR (definition: achieve molecular biological remission in the …
Contacts

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