LOT-CRT vs Conventional BiVP for Heart Failure
A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
Recruiting
N/A
Interventional Study
Heart Failure
Intraventricular Block
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 86 (estimated)
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University · Other
Who this trial is looking for
This trial is looking for people with chronic heart failure and a specific heart condition called intraventricular block to see if a new treatment, LOT-CRT, works better than a standard treatment. If you qualify, you will receive one of the treatments and be followed for at least six months.
Are You a Good Fit for This Trial?
You may be able to join if
- I have chronic heart failure.
- I have been on optimal medical therapy for at least 3 months.
- I am in NYHA class II-IV.
- My LVEF is 35% or less.
- I have sinus rhythm, though I may have occasional atrial fibrillation.
- My QRS duration is 150ms or more.
- I have intraventricular block.
You may not be able to join if
- I have had heart valve surgery or need it.
- I have had a mechanical tricuspid valve replacement.
- I have persistent or permanent atrial fibrillation or flutter.
- I have second or third degree atrioventricular block.
- I have had a heart attack in the past 3 months.
- My expected survival time is less than 12 months.
- I am pregnant or plan to conceive.
- I have ventricular septal hypertrophy.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effe…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Ischemic or non ischemic cardiomyopathy
2. Optimal medical therapy for at lest 3 months
3. NYHA class II-IV
4. LVEF≤35% as assessed by echocardiography
5. Sinus rhythm (may have paroxysmal atrial fibrillation)
6. QRS duration ≥ 150ms
7. Intraventricular block (NICD), QRS morp…
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