Effect of Celery Seed on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
Recruiting
Phase 2Interventional Study
Metabolic Syndrome
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
30 – 60
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
28 (estimated)
Sponsor
University of Guadalajara · Other
Who this trial is looking for
This trial is looking for people to test if celery seed can help with metabolic syndrome. Participants will need to meet specific health criteria and will be monitored over time.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 30 and 60 years old
I have been diagnosed with metabolic syndrome
I have a waist size of at least 80 cm (women) or 90 cm (men)
My fasting glucose is less than 126 mg/dL
My body mass index is between 25 and 34.9
I have had stable weight for the last 3 months
I have not been taking any medication for metabolic syndrome
I agree to participate and sign the consent form
You may not be able to join if
I am pregnant or breastfeeding
My total cholesterol is 240 mg/dL or higher
My triglycerides are 500 mg/dL or higher
My systolic blood pressure is 140 mmHg or higher
My diastolic blood pressure is 90 mmHg or higher
I have a history of kidney, liver, or thyroid disease
I take drugs or supplements that affect my metabolism
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The Metabolic Syndrome (MS) is a cluster of cardiometabolic risk factors, which include abdominal obesity, hyperglycemia, dyslipidemia, and high blood pressure. MS is a global health problem, it represents a risk factor for the progression of cardiovascular disease, which constitute the main cause of mortality in the world and in Mexico. The current treatment involves lifestyle changes and pharmac…
The Metabolic Syndrome (MS) is a cluster of cardiometabolic risk factors, which include abdominal obesity, hyperglycemia, dyslipidemia, and high blood pressure. MS is a global health problem, it represents a risk factor for the progression of cardiovascular disease, which constitute the main cause of mortality in the world and in Mexico. The current treatment involves lifestyle changes and pharmacological treatment for each of the components of MS, however, there is no single approved treatment to control all components. Celery seed (Apium graveolens L.) from the Apiaceae family contains the flavonoids apigenin and luteolin; essential oils such as d-limonene, selinene and phthalides such as 3-n-butylphthalide. Thanks to its bioactive components, celery seed has proven to be effective in treating individual MS disorders; however, most studies are in animal models and there are no clinical studies that evaluate its effectiveness on all components of the system. MS, insulin sensitivity and insulin secretion so it could appear as a new, safe and effective complementary therapy for the treatment of MS.
The aim of this study is to evaluate the effect of celery seed on the components of metabolic syndrome, insulin sensitivity, and insulin secretion.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients both sexes
* Age between 30 and 60 years
* Diagnosis of metabolic syndrome (MS) according to the IDF criteria: waist circumference: ≥80 cm (women) ≥90 cm (men), plus two or more of the following:
* Fasting glucose ≥ 100 mg/dL
* Triglycerides ≥150 mg/dL
* HDL-c:…
Inclusion Criteria:
* Patients both sexes
* Age between 30 and 60 years
* Diagnosis of metabolic syndrome (MS) according to the IDF criteria: waist circumference: ≥80 cm (women) ≥90 cm (men), plus two or more of the following:
* Fasting glucose ≥ 100 mg/dL
* Triglycerides ≥150 mg/dL
* HDL-c: Men ≤40 mg/dL, women ≤50 mg/dL
* Blood pressure ≥130/85 mmHg
* Body Mass Index from 25 to 34.9 kg/m²
* Stable weight at least the previous last 3 months (weight variation less than 10%)
* No pharmacological treatment for MS, insulin sensitivity and insulin secretion
* Acceptance and signing of informed consent
Exclusion Criteria:
* Pregnancy or breast-feeding
* Glucose ≥126 mg/dL
* Total cholesterol ≥240 mg/dL
* Triglycerides ≥500mg/dL
* Systolic blood pressure ≥140 mmHg
* Diastolic blood pressure ≥90 mmHg
* Drugs or supplements consumption with proven properties that modify the behavior of the study variables.
* History of kidney, liver or thyroid disease
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