miRNAs in Critical Limb Ischemia Research Study
miRNAs in Critical Limb Ischemia (miRNACLI)
Recruiting
Observational Study
Critical Limb Ischemia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 40 – 85
- Sex
- Any
- Study type
- Observational
- Participants needed
- 80 (estimated)
- Sponsor
- IRCCS Policlinico S. Donato · Other
Who this trial is looking for
This trial is looking for patients with critical limb ischemia who may need surgery or amputation. Participants will provide biopsies that researchers will use to study specific molecules related to their condition.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with critical limb ischemia.
- I am a candidate for popliteal exploration surgery or bypass.
- I have irreversible ischemia or gangrene of the lower limb and may need amputation.
- I have an infrarenal abdominal aortic aneurysm and am undergoing surgery for it.
You may not be able to join if
- I am pregnant.
- I have a genetic disease.
- I have cancer.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
For the present study, 40 patients affected by critical limb ischemia of different severity will be enrolled: patients affected by critical limb ischemia undergoing subgenual femoropopliteal bypass; patients suffering from terminal ischemia causing gangrene and therefore undergoing major amputation of the lower limb. Biopsies from the first 20 enrolled patients will be used for miRNA profiling. Th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Cases:
* patients affected by CLI candidates for popliteal exploration surgery and/or subgenual femoropopliteal bypass.
* Patients affected by CLI with irreversible ischemia and/or distal gangrene of the lower limb candidates for major amputation of the lower limb.
Controls:
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Contacts