Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline
Recruiting
N/A
Interventional Study
Early Syphilis, Latent, Serological Relapse After Treatment
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 688 (estimated)
- Sponsor
- National Taiwan University Hospital · Other
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About This Trial
This randomized controlled superiority study will be conducted during 2023-2025. The eligible participants are adult people living with HIV (PLWH) who are newly diagnosed with early syphilis. Participants will be randomized in a 1:1 ratio to receive single-dose benzathine penicillin G (BPG) (2.4 MU intramuscularly once) plus doxycycline (100 mg orally twice daily for 7 days) or single-dose BPG. Th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* People living with HIV (PLWH) aged ≥18 years with early syphilis
* Confirmed by a positive RPR titer with a reactive TPPA assay
Exclusion Criteria:
* PWH with RPR titers of \<4
* Subject has latent syphilis of unknown duration, late latent syphilis, or evidence of neurosyphi…
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