Randomized Controlled Trial for Wheat Oral Immunotherapy

Inclusion Criteria: First stage to diagnose immediate-type wheat allergy: * 1-17 years old * History of adverse reactions within four hours after foods containing wheat or gluten * IgE sensitization to wheat by positive SPT or serum sIgE level * Parent give informed written consent to participate Second stage to commence oral immunotherapy of wheat for 12 months: * Failed wheat double-blind, placebo-controlled food challenge (DBPCFC) under stage I * 3-17 years old * Body weight more than 8 kg * IgE sensitization to wheat by positive SPT or serum sIgE level * Parent give informed written consent to participate Exclusion Criteria: First stage for diagnosis of immediate-type wheat allergy: * Eczema flare or severe allergic reactions within 4 weeks * Intake of antihistamines within 1 week * Systemic corticosteroid treatment within 4 weeks * Intravenous immunoglobulin, systemic immunosuppressive or biologic within 3 months * Inability to follow the requirements and expected procedure of DBPCFC Second stage of wheat oral immunotherapy for 12 months: * History of severe anaphylaxis to wheat * Severe anaphylaxis during double-blind placebo-controlled wheat challenge from stage 1 * Active medical conditions * Use of beta-blockers or angiotensin-converting enzyme inhibitors * Have received other food oral immunotherapy treatment within 12 months * Eczema flare or severe allergic reactions within 4 weeks; * Intake of antihistamines within 1 week * Systemic corticosteroid treatment within 4 weeks; * On Intravenous immunoglobulin, systemic immunosuppressive or biologic within 3 months * Inability to follow the requirements and protocol for wheat oral immunotherapy