Brain Stimulation for Apathy in Parkinson Disease

Apathy in Parkinson Disease TMS Study

Recruiting N/A Interventional Study
Parkinson Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
55 – 80
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
100 (estimated)
Sponsor
University of North Carolina, Chapel Hill · Other
Who this trial is looking for

This trial is looking for people with Parkinson's disease who have motivation problems. Participants will answer questions, perform tasks, and receive brain stimulation to see if it helps with their apathy.

Are You a Good Fit for This Trial?
Must be taking Dopaminergic medication
Rules you out DementiaEpilepsy

You may be able to join if

  • I have been diagnosed with Parkinson Disease.
  • I have had symptoms for at least 4 years.
  • I am taking medications for Parkinson Disease.
  • I have been stable on my medications for at least 4 weeks.
  • I can give my informed consent in English.
  • If I am female, I have not had a menstrual period in over 12 months or I will use effective contraception during the study.

You may not be able to join if

  • I cannot provide informed consent.
  • I cannot perform the effort task.
  • I have dementia.
  • I have a history of epilepsy or brain surgery.
  • I have severe tremor or dyskinesia that would interfere with EEG.
  • I have significant medical or neurological conditions that cause parkinsonism.
  • I have any central nervous system disease that may interfere with the study.
  • I have any implanted metal devices.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Disease patients? 2. Is there a link between brain signals and apathy? Participants will * complete…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Diagnosis of idiopathic Parkinson Disease. * At least 4 years of symptoms. * On dopaminergic medication for Parkinson Disease. * Stable on dopaminergic medication and other medications which may influence apathy (such as selective serotonin re-uptake inhibitors, stimulant medi…
Contacts

Cole Shumate

919-445-0979

shumatec@neurology.unc.edu

CONTACT

Miriam Sklerov, MD

984-974-4401

miri@email.unc.edu

CONTACT