Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Recruiting
Phase 4
Interventional Study
Salt-Sensitivity of Blood Pressure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 40 – 60
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 120 (estimated)
- Sponsor
- University of Delaware · Other
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Check Your Eligibility
About This Trial
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channe…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age: \> 40 years or \< 60 years
* Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
* BMI: \> 18.5 kg/m2 or \< 35 kg/m2
* Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
* No history of cardiovascular, renal, metabolic, or neurological disease
Exclusion Criteria:
* Age: \< 40…
Contacts