No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 75
Sex
Any
Study type
Observational
Participants needed
370 (estimated)
Sponsor
Fudan University · Other
Who this trial is looking for
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This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) with the identification number ECTOP-1021. The primary objective of the study is to assess the overall survival of patients with multifocal ground-glass opacities by employing a active surveillance approach rather than opting for surgical resection.
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Eligibility Criteria
Inclusion criteria Patients eligible for enrollment in the study are required to meet all the following criteria.
1. Demonstrates the following on thin-section computed tomography (TSCT) scan:
1. Presence of three or more GGNs (bilateral lesions are permitted).
2. All lesions have remained s…
Inclusion criteria Patients eligible for enrollment in the study are required to meet all the following criteria.
1. Demonstrates the following on thin-section computed tomography (TSCT) scan:
1. Presence of three or more GGNs (bilateral lesions are permitted).
2. All lesions have remained stable without regression or enlargement for at least 3 months.
3. The dominant lesion (the lesion with the largest maximum tumor diameter) has a maximum tumor diameter \>=0.6cm and \<=2cm.
4. CTR \<=0.25 in all lesions.
5. No lymph node with a diameter \>1cm in the mediastinal view.
6. Not adjacent to the pleura in dominant lesion and no sign of pleural retraction in any lesions.
2. Aged 18-75 years.
3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
4. Has not previously undergo any anti-tumor drug or radiation therapy.
5. Written informed consent.
Exclusion criteria Patients will be excluded if they meet any of the following criteria.
1. History of any prior malignancies within the past 5 years.
2. History of lung surgery.
3. History of interstitial pneumonia, pulmonary fibrosis or other severe pulmonary diseases.
4. Presence of severe or uncontrolled diseases that may possibly reduce the 10-year life expectancy.
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