Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children
Recruiting
N/AInterventional Study
Obsessive-Compulsive Disorder in Children
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
8 – 12
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Columbia University · Other
Who this trial is looking for
This trial is looking for children ages 8 to 12 with obsessive-compulsive disorder (OCD). Participants will use a fun computer game for 25 minutes a day, 5 days a week, for 4 weeks to help improve their symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 8 and 12 years old.
I have been diagnosed with obsessive-compulsive disorder (OCD).
My OCD causes me significant distress.
I have symptoms that are clinically significant.
I am not currently taking any psychotropic medication.
I have not received psychotherapy for OCD recently.
I can manage a treatment-free period during the study.
I can give my informed assent to participate.
You may not be able to join if
I have had major depressive disorder or PTSD.
I currently have suicidal thoughts.
I am pregnant or nursing.
I have a major medical or neurological condition.
I have a positive urine test for illegal drugs.
I have braces or any metallic device.
I have an IQ below 80.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This study aims to examine the effects of a game-like program called cognitive control training (CT) for children with obsessive compulsive disorder (OCD). Children enrolled in this study will receive 4 weeks of the at-home computerized cognitive training program (AKL-T01) delivered on iPad (25 minutes/day, 5 days/week). Styled as a child-friendly video game, AKL-T01 CT taps focused attention, res…
This study aims to examine the effects of a game-like program called cognitive control training (CT) for children with obsessive compulsive disorder (OCD). Children enrolled in this study will receive 4 weeks of the at-home computerized cognitive training program (AKL-T01) delivered on iPad (25 minutes/day, 5 days/week). Styled as a child-friendly video game, AKL-T01 CT taps focused attention, response inhibition, and working memory using a series of games to engage cognitive control processes. Children will complete the NIH Toolbox prior to, mid (2-weeks), and post-CT (4-weeks). Participants will complete MRI scans pre- and post-CT and then be offered a 12-week course of gold-standard Cognitive behavioral therapy with exposure and response prevention (or community referrals) after CT. The long-term goal of this study is to test how this CT intervention may enhance cognitive control capacity to reduce symptoms and improve response to cognitive behavioral therapy with exposure and response prevention in children with OCD.
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Eligibility Criteria
Inclusion Criteria:
* Ages between 8 and 12 years;
* Clinically significant OCD as the principal problem. This is defined as follows: they must meet DSM-V criteria for OCD as assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Ver…
Inclusion Criteria:
* Ages between 8 and 12 years;
* Clinically significant OCD as the principal problem. This is defined as follows: they must meet DSM-V criteria for OCD as assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version (K-SADS-PL). OCD must be the primary source of interference and distress (based on clinical evaluation with K- SADS-PL and Children's Yale-Brown Obsessive Compulsive Scale (C-YBOCS) and they must have clinically significant symptoms (i.e., C-YBOCS) ≥ 16;
* Not on psychotropic medication (either treatment-naïve or free of psychotropic medication for at least three months) and not receiving current psychotherapy for OCD;
* Ability to tolerate a treatment-free period (i.e., no treatment other than study CBT);
* Capacity to provide informed assent
Exclusion Criteria:
* Current or past diagnosis of major depressive disorder, PTSD, substance/alcohol abuse, psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, substance/alcohol dependence, or any other Axis I disorder not listed above;
* Active suicidal ideation;
* Females who are pregnant or nursing;
* Any major medical or neurological problem (e.g., unstable hypertension, seizure disorder, head trauma); -Positive urine screen for illicit drugs;
* Presence of metallic device or dental braces;
* IQ \<80;
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