Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Recruiting
Observational Study
Opioid Use Disorder
Sleep Disturbance
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Observational
- Participants needed
- 200 (estimated)
- Sponsor
- University of Alabama at Birmingham · Other
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About This Trial
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use disorder, leading to high rates of relapse. In this project, we will investigate a special set of photosensitive neurons in the retina as an underlying mechanism for circadian rh…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Adults (18+)
2. prescribed one of three medications for opioid use disorder (methadone, XR-NTX, buprenorphine) or healthy control
3. stable on MOUD (no dose change) for the past month
4. positive on urine drug screen (UDS) for buprenorphine or methadone if prescribed those me…
Contacts