Stress Responses in People With Alcohol Use Disorder
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
Recruiting
N/AInterventional Study
Alcohol Use DisorderStress ReactionSocial StressCravingRelapseAddiction, AlcoholRisk Behavior
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
Central Institute of Mental Health, Mannheim · Other
Who this trial is looking for
This trial is looking for people who struggle with alcohol use and want to understand their stress responses better. Participants will undergo stress tests and assessments while being monitored in a study environment.
Are You a Good Fit for This Trial?
Rules you outBipolar disorderPsychotic disorderSchizophreniaSevere head injurySevere central nervous system disordersSevere somatic disorders
You may be able to join if
I am between 16 and 65 years old.
I have at least 2 symptoms of alcohol use disorder.
I can speak and understand German.
I can understand the study and give my permission.
I am willing to use a study smartphone.
You may not be able to join if
I currently use drugs or medications that affect the brain.
I have conditions that prevent me from having an MRI.
I have a history of bipolar disorder or psychosis.
I have had severe head injuries or serious brain or body disorders.
I am pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are:
What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to:
* alcohol craving?
* alcohol use?
* their modu…
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are:
What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to:
* alcohol craving?
* alcohol use?
* their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior?
Participants will:
* be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test
* be exposed to their favorite drink in a bar lab environment
* be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing
* conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.
Trial Locations
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Eligibility Criteria
Inclusion criteria are:
* age between 16 and 65 years
* meeting at least 2 criteria of an alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), yet without the need for a therapeutic intervention
* fluency in German
* able to understand…
Inclusion criteria are:
* age between 16 and 65 years
* meeting at least 2 criteria of an alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), yet without the need for a therapeutic intervention
* fluency in German
* able to understand the study procedures and give informed consent
* willingness to use a study smartphone
Exclusion criteria are:
* current use of drugs or medications that interact with the central nervous system or the glucocorticoid system
* contraindications for magnetic resonance imaging
* medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis
* medical history of severe head injury or other severe central nervous system disorders or other severe somatic disorders (e.g. liver cirrhosis)
* pregnancy
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