Oral Ketones for Heart Failure and Type 2 Diabetes

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

Recruiting Early Phase 1 Interventional Study
Type 2 Diabetes Heart Failure, Reduced Ejection Fraction
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 80
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
10 (estimated)
Sponsor
The University of Texas Health Science Center at San Antonio · Other
Who this trial is looking for

This trial is looking for adults with heart failure and diabetes to see if oral ketones can improve heart function. Participants must be stable on heart failure medications and meet certain health criteria.

Are You a Good Fit for This Trial?
Must not be taking SGLT2i medications

You may be able to join if

  • I am between 18 and 80 years old.
  • I have heart failure.
  • I have type 2 diabetes.
  • I have a stable dose of heart failure medications.
  • My blood pressure is less than 145/85 mmHg.
  • My BMI is between 23 and 38.
  • My blood sugar test is between 6.0% and 10.0%.
  • I am willing to use contraception if I am a woman of child-bearing age.

You may not be able to join if

  • I have taken heart medications that might worsen my condition.
  • I am pregnant, breastfeeding, or planning to become pregnant.
  • I am allergic to the study drugs.
  • I misuse drugs or alcohol.
  • I cannot provide written consent.
  • I have had cancer in the last 5 years (except certain skin cancers).
  • I have had a cardiovascular event in the last 3 months.
  • I have major organ diseases or physical limitations that affect my participation.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial

This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.

Trial Locations
Loading…

Loading trial locations…

Eligibility Criteria
Inclusion Criteria: * Subjects must be on a stable dose of guideline-directed medications for Heart Failure (HF). * Patients will have an established diagnosis of HF before the screening visit, documented by an acceptable imaging modality in the last 6 months. * Age = 18-80 y * Body Mass Index (BMI…
Contacts

Carolina Solis-Herrera, MD

210-567-4900

solisherrera@uthscsa.edu

CONTACT