Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

Inclusion Criteria: 1. Age 20-65 years old; 2. ASA classification is grade I-III; 3. Elective surgery is proposed 4. BMI of 19-30 kg/m2; 5. Patients who agreed to enroll in this study voluntarily Exclusion Criteria: 1. Those who are known to be allergic to the drug ingredients in this study and their allergic constitution; 2. Allergic history of general anesthesia drugs, opioid drugs, non-steroidal drugs; 3. History of neurological diseases; History of chronic pain; Drug and alcohol addiction; A long history of opioid use; Opiates were given 48 hours before surgery; 4. ASA rating of IV or V; 5. Coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, electrolyte abnormalities; 6. History of gastrointestinal disease (peptic ulcer, Crohn's disease, ulcerative colitis); 7. Respiratory insufficiency, respiratory failure; 8. Patients who refused to use intravenous PCA for analgesia; 9. Pregnant or lactating women; 10. BMI\<18 kg/m2 or BMI\>30kg/m2; 11. Poor compliance, unable to complete the experiment according to the study plan; 12. Participants who have participated in clinical trials of other drugs within the last 4 weeks; 13. Any circumstances deemed unsuitable for inclusion by the researcher for any reason.