PEPPI Study: Identification of Women at Risk for Placental Dysfunction
Recruiting
Observational Study
Pre-EclampsiaIntrauterine Growth RestrictionPolycystic Ovary SyndromeIron-deficiencyCardiovascular DiseasesHypertensive Disorder of PregnancyProteinuria in Pregnancy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Sex
Any
Study type
Observational
Participants needed
3,000 (estimated)
Sponsor
Oulu University Hospital · Other
Who this trial is looking for
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Answer a few quick questions to see if you may meet the eligibility requirements.
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population.
Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome
Trial Locations
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Status
Eligibility Criteria
Mothers
Inclusion Criteria for PEPPI-study
* Pregnant (first trimester)
* Understands Finnish
* ≥18 years
* Signed informed consent
Exclusion Criteria
* Multiple pregnancy
* Miscarriage/termination of the index pregnancy
* No first trimester blood sampling
Inclusion Criteria for FERPPI-study
*…
Mothers
Inclusion Criteria for PEPPI-study
* Pregnant (first trimester)
* Understands Finnish
* ≥18 years
* Signed informed consent
Exclusion Criteria
* Multiple pregnancy
* Miscarriage/termination of the index pregnancy
* No first trimester blood sampling
Inclusion Criteria for FERPPI-study
* Participates in PEPPI-study (criteria above)
* Blood samples at first and third trimester of pregnancy
* Permits blood sampling from the umbilical cord when the baby is born
Exclusion Criteria
* No first or third trimester blood sampling
* No umbilical cord blood sample after baby is born
Fathers
Inclusion Criteria
* Biological father to the child born for the mother who participated in PEPPI study
* ≥18 years
* Signed informed consent
Exclusion Criteria
• Does not understand Finnish
Children
Inclusion Criteria for PEPPI-study
* Born to mother who participated in PEPPI study
* Signed informed consent from parent(s)
Exclusion Criteria
• No consent from parent(s)
Inclusion Criteria for PEPPI-offspring study • Mother in risk-, control-, or PCOS group during PEPPI-study with ultrasound information at gestational weeks 30-32 or a mother who developed pre-eclampsia during the pregnancy regardless of their study group during PEPPI-study
Exclusion Criteria
• Mother/father declines participation
Inclusion Criteria for FERPPI-study
* Signed informed consent from parent(s)
* Mother has blood samples taken at first and third trimester (iron status)
* Child has blood samples taken at birth and at 3 months of age
Exclusion Criteria
* No consent from parent(s)
* No blood samples from mother
* No blood samples from child
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