Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery

Inclusion criteria 1. Aged between 50 and 80 years, male or female; 2. Patients undergoing elective cardiac surgery; 3. Have signed the informed consent form (ICF). Exclusion criteria 1. Patients undergoing emergency surgery; 2. Patients undergoing deep hypothermic circulatory arrest surgery; 3. Preoperative predicted mortality \>3% according to European System for Cardiac Operative Risk Evaluation II (EuroSCORE II); 4. Patients undergoing off-pump coronary artery bypass grafting (off-pump CABG) surgery; 5. Patients undergoing left or right ventricular outflow tract obstruction surgery; 6. Patients undergoing complex corrective surgery for congenital heart disease; 7. Patients with an expected CPB exceeding 180 minutes or an anticipated aortic cross-clamp time exceeding 120 minutes; 8. Patients expected to have a postoperative endotracheal tube removal time exceeding 24 hours; 9. Patients with prolonged fasting or inability to self-feed; 10. A history of malignant tumor; 11. Patients with unstable preoperative vital signs requiring intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO)assistance, or endotracheal tube-assisted ventilation; 12. A history of cardiac surgery; 13. Patients with preoperative gastrointestinal symptoms, such as nausea, vomiting and diarrhea; 14. Patients with a history of dialysis before surgery; 15. Patients with a history of atrial fibrillation before surgery; 16. Patients on long-term hepatorenal protective medications; 17. Patients with hepatic and renal insufficiency (Child-Pugh class B or C, estimated glomerular filtration rate \<35 mL/min/1.73 m2); 18. Patients with abnormal baseline inflammatory markers \[interleukin-6 (IL6) \>10 pg/mL, procalcitonin (PCT) \>0.5 ng/mL, C reactive protein (CRP) \>10 mg/L\]; 19. Patients diagnosed with infectious diseases, inflammatory immune diseases, or tumor; 20. Patients who have received immunosuppressive or anti-inflammatory treatment; 21. Patients allergic or intolerant to colchicine; 22. Breastfeeding or pregnant women; 23. Other situations deemed inappropriate for participation in the study by the investigator.